Petopentia natalensis is an excellent climbing plant in culture as it stands the extremes of heat and cold better than most plants, it can quickly become overwhelming, it is better to install support for stems that can reach 7 meters, and when in bloom it is a very interesting plant. 
Growth rate: Although the vines can reach lengths of 15 m in the wild, cultivated plants generally extend 1,5-2 m, twisting around supports to which they cling or hanging down in attractive cascades from suspended pots. 
Potting medium: It benefits from being potted up in a very well-draining and porous potting medium that allows some air to get to the roots; typical mixes include, peat, with some fibrous soil and sand along with large-grade drainage material such as perlite, pumice, or lava grit. The medium needs to be moisture-retentive.
Fertilization: Need a perfect fertilizer diet including all micro nutrients and trace elements. Micronutrient deficiencies are occasional problems. Micronutrient deficiencies only show up on soil with a high pH. 
Watering: With its succulent tubers it's quite adapt at storing water for longish periods of time between waterings. Water regularly in summer, but do not overwater ( wet-sensitively) and let the plants to dry out between watering and then water again. Its roots are easily lost in pots that stay damp for any length of time. Keep quite dry with ample airflow in winter (It would probably tolerate one watering a month). In the rest period no high atmospheric humidity. Care must be taken with watering as they tends to become swollen and untidy in growth habit if given too much water and shade.