Pilosocereus palmeri grows well and is a very vigorous growers (one of the quickest growing cactus), and is possible to increase the speed of growth to some extent by providing adequate amount of water, warmth, and an all-purpose liquid fertilizer diluted half strength during the active growing season, but it’s susceptible to rotting if too wet. It likes a sunny position also blasting sun in summer. If grown indoor provide 4 to 6 hours, or more, direct morning or afternoon sun. It should be watered regularly in Summer and kept drier in Winter. It like pots with generous drain holes, need a very porous, slightly acidic potting medium (add pumice, vulcanite, and perlite). It can be grown outdoors in frost-free climates, needs anyway to kept above 12 °C and dry in winter. But it can tolerate temperatures down to 5° C (or even 0° C) for very short periods if very dry and ventilated. Manteinance: Repot every two years.